Abstract: OBJECTIVE To study the results of logistic regression of related factors of surgical site infections (SSI) in patients undergoing open heart surgery, and to provide related evidenc for reducing SSI. METHODS A total of 210 patients with open heart surgery treated in hospital from Mar. 2015 to Oct. 2015 were selected as study subjects. Related factors of the occurrence of infections were analyzed, and logistic regression analysis was used to analyze the risk factors associated with infections. The results were statistically analyzed by software SPSS20.0. RESULTS Among the 210 patients, surgical site infections occurred in 43 patients with an infection rate of 20.48%. Superficial wound infections accounted for 60.47% which was significantly higher than 34.88% of the deep infections and higher than 4.65% of the mediastinal infection (P<0.05).Logistic regression analysis showed that the conditions of the operation time > 3h, 3d of high fever symptoms after surgery, ICU time after surgery > 3d, high blood glucose after operation and continuous suture on the incision were the risk factors of SSI. CONCLUSION Superficial wound infection is the main way of SSI after open heart surgery, and the operation time > 3h, 3d of high fever symptoms after surgery, ICU time after surgery > 3d, high blood glucose after operation and continuous suture on the incision were the risk factors of SSI.