Abstract: OBJECTIVE To investigate the risk factors for nosocomial infections in nasopharyngeal carcinoma patients after radiotherapy and explore the prevention strategies so as to provide guidance for prevention of nosocomial infections. METHODS A total of 204 nasopharyngeal carcinoma patients who underwent the radiotherapy in the hospital from Aug 2012 to Aug 2015 were recruited as the study objects, then the incidence of nosocomial infections was retrospectively analyzed, the genders, age, disease courses, complications, treatment process, infection sites, and distribution of pathogens were taken for statistics, the risk factors for the nosocomial infections in the nasopharyngeal carcinoma patients undergoing the radiotherapy were observed by means of multivariate logistic regression analysis, and the statistical analysis of all the data was performed with the use of SPSS18.0 software. RESULTS Of the 204 patients, 163 had the nosocomial infections after the radiotherapy, with the infection rate 79.9%; the patients with grade 3 infections accounted for 38.2%, and the patients with oral cavity infections accounted for 63.2%. Totally 192 strains of pathogens were isolated, of which 66.7% were fungi. The independent risk factors for the nosocomial infections in the nasopharyngeal carcinoma patients after the radiotherapy included the no less than 60 years of age, length of hospital stay no less than 60 days, conventional radiotherapy, concurrent chemotherapy, invasive operation, TNM stage varying from Ⅲ to Ⅳ, use of 2 types of antibiotics, and use of immunosuppressants (P<0.05). CONCLUSION The incidence of the nosocomial infections is relatively high in the nasopharyngeal carcinoma patients after the radiotherapy. It is necessary to conduct the preventive nursing based on the risk factors for the nosocomial infections and focus on the rationality of treatment programs so as to reduce the risk of the nosocomial infections and improve the quality of prognosis.