Abstract: OBJECTIVE To analyze the clinical value of procalcitonin (PCT) combined with C-reactive protein (CRP) in diagnosis of central nervous system infectious diseases in children. METHODS A total of 85 children with central nervous system infectious diseases who were treated in the hospital from Sep 2012 to Sep 2015 and 50 children healthy children who received physical examination during the same period were recruited as the study objects and respectively assigned as the case group and the control group. The levels of serum PCT and CRP were compared between the two groups of patients, and the levels of serum PCT and CRP of the children in the case group were observed before and after the treatment. RESULTS In the case group, totally 21 children were diagnosed with suppurative meningitis, and 64 children were diagnosed with viral meningitis. The levels of serum PCT and CRP of the children with suppurative meningitis were significantly higher than those of the children in the control group and the children with viral meningitis (P＜0.05). There was no significant difference in the level of serum PCT or CRP between the children with viral meningitis and the children in the control group. The levels of serum PCT and CRP of the children with suppurative meningitis were significantly reduced after the treatment(P＜0.05); there was no significant difference in the level of serum PCT or CRP between the children with suppurative meningitis and the children with viral meningitis after the treatment. CONCLUSION The PCT combined with CRP has high clinical value in diagnosis of the central nervous system infectious diseases in the children, judgment of prognosis, and evaluation of efficacy; it is worthy to be promoted.