Abstract: OBJECTIVE To investigate the effects of different perfusion pressures during percutaneous nephrolithotomies on the postoperative infection status and renal functions, so as to provide evidence for the clinical selection of perfusion pressure. METHODS A total of 70 patients treated with PCNL in our hospital from Oct.2014 to Oct.2015 were retrospectively analyzed, and divided into two groups, including 33 patients in high perfusion pressure group, and the other 37 patients in low perfusion pressure group. Vital signs, shock index, leukocyte count, neutrophil percentage and serum creatinine were analyzed to draw a conclusion. RESULTS Temperature, neutrophil percentage, serum creatinine of high perfusion pressure group were significantly higher than those of low perfusion pressure group after operation of 24 h, 48 h and 72 h (P<0.05). Shock index of high perfusion pressure group was significantly higher than that of low perfusion pressure group after operation of 24 h, 48 h and 72 h (P<0.05). Shock indexes after operation of 24 h and 48 h were significant different (P<0.05), however, there was no significant difference after 72h. Sphygmus, systolic blood pressure and leukocyte count had no statistically significant difference of the two groups after operation of 24 h, 48 h and 72 h. CONCLUSION The temperature, neutrophil percentage, serum creatinine and shock index of high perfusion pressure group were higher than those of low perfusion pressure group, which means the infection status is more serious, and the renal function damage is also relatively serious. The difference of the shock index had no significance after 72 h, which means the patients gradually improved with the fluid infusion and anti-infection treatments.