Abstract: OBJECTIVE To explore the impact of pidotimod on serum procalcitonin (PCT), C-reactive protein (CRP), prealbumin (PA), and white blood cell (WBC) counts of children with bacterial pneumonia so as to provide guidance for treatment of the bacterial pneumonia. METHODS A total of 80 children with bacterial pneumonia who were treated in the hospital from Feb 2015 to Oct 2015 were enrolled in the study and randomly divided into the observation group and the control group and the observation group, with 40 cases in each group.The two groups of children were given the therapies such as anti-infection, anti-tussive, dissipating phlegm, relieving asthma, and oxygen uptake; the observation group was treated with additional pidotimod.The changes of serum PCT, CRP, PA, and WBC were observed and compared between the two groups of patients before the treatment and after the treatment for 1 week. RESULTS There was no significant difference in the serum PCT, CRP, PA, or WBC between the two groups before the treatment; the levels of PCT, CRP, and WBC declined after the treatment, however, the level of PA was elevated, the above indexes of the observation group were improved more significantly than those of the control group after the treatment(P＜0.05).The subsided time of fever, time of disappearance of cough, time of disappearance of lung rales, and length of hospital stay, as well as time of recovery of PCT, CRP, PA, and WBC were shorter in the observation group than in the control group (P＜0.05).The total effective rate of treatment of the observation group was 95.00%, higher than 77.50% of the control group (P＜0.05). CONCLUSION The use of pidotimod for authilliary treatment of the children with bacterial pneumonia may facilitate the improvement of levels of serum PCT, CRP, PA, and WBC as well as the clinical symptoms, shorten the disease course, and improve the therapeutic effect.