Abstract: OBJECTIVE To explore the correlation between the changes of high-sensitivity C-reactive protein (h-CRP) and procalcitonin (PCT) and the prognosis of the splenectomy, pericardial devascularization patients with postoperative infection so as to provide guidance for clinical control of the postoperative infections. METHODS A total of 68 patients who received the splenectomy, pericardial devascularization from Dec 2014 to 2015 and had postoperative infections were enrolled in the study and assigned as the experimental group, meanwhile, 68 patients who received the splenectomy, pericardial devascularization but did not have infection were set as the control group. The PCT level of the two groups of patients was determined by using electrochemiluminescence immunoassay, and the h-CRP level was determined with the use of immunoturbidimetric assay. The levels of h-CRP and PCT were compared between the two groups of patients, and their correlation with the prognosis was observed. RESULTS The PCT level of the experimental group was (16.38±4.47)ng/ml, significantly higher than (6.86±3.13)ng/ml of the control group; the h-CRP level of the experimental group was (45.30±19.70)mg/L, significantly higher than (22.10±5.30)mg/L of the control group; the WBC counts of the experimental group were (17.40±3.40)×10⁹/L, significantly more than (11.30±2.60)×10⁹/L of the control group; the APCHEⅡ score of the experimental group was (24.56±7.79), significantly higher than (13.12±6.21) of the control group(P<0.05). The PCT and h-CRP of the patients with postoperative infection in the experimental group were positively correlated with the APCHEⅡ score after the admission to the hospital (r=0.642 and 0.547); the WBC was not correlated with the APCHEⅡ. The levels of PCT and h-CRP of the experimental group were significantly higher than those of the control group on Day 1, 3, and 5 (P<0.05); the levels of PCT and h-CRP of the experimental group reached the peak on Day 3 and then showed downwards. CONCLUSION The h-CRP and PCT of the splenectomy, pericardial devascularization patients with postoperative infection are closely associated with the prognosis. It is necessary to strengthen the monitoring of the h-CRP and PCT levels so as to reduce the infection rate.