Abstract: OBJECTIVE To explore the effects of different intraoperative insulation methods on body temperature, coagulation, and surgical site infections in patients undergoing gastrointestinal surgery so as to offer the more effective insulation method for the patients undergoing the gastrointestinal surgery. METHODS A total of 240 patients who were treated in the hospital and received the gastrointestinal surgery from Jan 2012 to Oct 2015 were enrolled in the study and randomly divided into the observation group and the control group, with 120 cases in each group.The observation group was treated with covering with quilts combined with warming blanket for double insulation, while the control group was only given covering with quilts for insulation.The change of body temperature, incidence of hypothermia, thrombin time (TT), prothrombin time (PT), and activated partial thromboplastin time (APTT) were observed and compared between the two groups of patients before the surgery, at 30, 60, 90 min during the surgery, and at the end of surgery; the blood loss volume was compared during the surgery and after the surgery for 1, 3, 6, 12, and 24 hours; the incidence of surgical site infections was compared between the two groups of patients. RESULTS The intraoperative body temperature did not change significantly in the observation group, significantly higher than that in the control group (P＜0.05).The hypothermia occurred in 11 cases in the observation group during the perioperative period, with the incidence rate 9.2%; it occurred in 83 cases in the control group, with the incidence rate 69.2%, and there was significant difference between the two groups (P＜0.05).There was significant difference in the perioperative blood loss volume between the observation group and the control group (P＜0.05).The TT, PT, and APTT of the observation group changed significantly during the perioperative period, as compared with the control group(P＜0.05).The incidence of surgical site infections was 2.5% in the observation group, significantly lower than 16.7% in the control group(P＜0.05). CONCLUSION As for the patients undergoing gastrointestinal surgeries, the intraoperative use of warning blanket may increase the heat production, facilitate the maintenance of body temperature, reduce the incidence of hypothermia, decrease the blood loss volume during the perioperative period, improve the coagulation disorders, and reduce the incidence of surgical site infections.