Abstract: OBJECTIVE To explore the effect of continuous closed irrigation and drainage on posterior spinal surgery patients with postoperative infection and observe the influence on inflammatory stress state. METHODS From Jan 2012 to Dec, 2015, a total of 60 patients who underwent the posterior spinal surgery and were complicated with postoperative infection were enrolled in the study and randomly divided into the experimental group and the control group, with 30 cases in each group. After the infected tissues were removed, the experimental group was placed with continuous closed irrigation and drainage system, the control group was treated with covering wounds with Vaseline gauze and was given sensitive antibiotics. The blood tests were carried out before the treatment and after the treatment for 1, 3, and 5 weeks so as to determine the levels of procalcitonin (PCT), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin 6 (IL-6), and tumor necrosis factor α(TNF-α). RESULTS The wound healing rate of the experimental group was 90.00%, significant higher than 63.33% of the control group. The average wound healing time of the experimental group was (18.46±3.24) days, significantly shorter than (23.45±5.93) days of the control group(P<0.05). The levels of PCT, CRP, TNF-α,IL-6, and ESR as well as white blood cell counts were remarkably reduced after the treatment for 1, 3, and 5 weeks (P＜0.05). The above indexes of the two groups of patients returned to normal after the surgery for 5 weeks. The levels of PCT, CRP, TNF-α,IL-6, and ESR as well as white blood cell counts were significantly lower in the experimental group than in the control group after the treatment for 1, 3 weeks (P＜0.05). CONCLUSION As compared with the traditional conservative therapy, the continuous closed irrigation and drainage can achieve more significant effect on control of the postoperative infection in the patients undergoing the posterior spinal surgery and reduce the body inflammatory stress state.