Abstract: OBJECTIVE To investigate the effects of clinical pulse pressure on prognosis of emergency ICU septic shock patients, so as to provide the basis for clinical treatment. METHODS A total of 120 patients with septic shock in EICU of hospital from Jan.2013 to Dec.2015 were selected, and divided into survival group(72 cases) and death group(48 cases) according to the outcome of treatment. Patients were monitored mean arterial pressure (MAP) and the critically ill APACHEⅢ score. The data were analyzed by SPSS 19.0. RESULTS The mean arterial pressure and APACHEⅢ score of survival group were (75.02±6.42) mmHg and (54.63±6.73) points, which were respectively(61.53±6.34) mmHg and (92.53±8.03) points in the death group (P<0.05). The arterial pressure of survival group was increased with the increasing of length of stay in hospital, while the arterial pressure was decreased of death group (P<0.05). With the decline of mean arterial pressure, APACHEⅢ rates rose, and the difference was significant (P<0.05). CONCLUSION The mean arterial pressure and septic shock severity in patients with septic shock is positively correlated, it may reflect the prognosis of patients to some extent, so clinical prognosis can be predicted according to pulse pressure.