Abstract: OBJECTIVE To discuss the guidance value of RASS score for early goal-directed therapy(EGDT) on the patients with septic shock, so as to guide the clinical treatment. METHODS A total of 92 patients with septic shock from Oct. 2013 to Jun. 2015 admitted to ICU in our hospital were selected. Patients were divided into test group and control group according to the random number table, with 46 patients in each group. Test group was given the treatment of sedation guided by RASS score+ EGDT, while control group was given the treatment of conventional sedation + EGDT. After observation for 28 days, the mechanical ventilation time, length of ICU, ICU hospitalization costs, mortality and multiple organ dysfunction syndrome(MODS) incidences were compared between the two groups, and the 6 h, 24h fluid volume of two groups were observed, the changes of liver function and renal function of two groups before and after treatment were measured. RESULTS The mechanical ventilation time, staying time of ICU, hospital total costs in test group were significantly lower than control group (P<0.05). The 28-day mortality rate and incidence of MODS in test group were 15.2% and 34.8%, which were significantly lower than those in control group 41.3% and 60.9% (P<0.05). The total infusion at 6 h, and 24 h of test group were significantly higher than those in control group. The liver and renal function index of two groups before and after treatment showed a trend from rise to decline, with maximum value at 24 h after treatment. CONCLUSION RASS score has great guidance value for patients with septic shock undergoing EGDT, which could shorten the duration of mechanical ventilation of patients, reduce the mortality rate, and improve the prognosis of patients.