Abstract: OBJECTIVE To discuss the risk factors and prognosis for lung infection in patients with stroke, so as to provide a theoretical basis for stroke patients with pulmonary infection clinical treatment. METHODS A total of 253 cases of stroke patients treated in the hospital from Jun. 2010 to Jul. 2015 were selected as the research objects, grouped into infection group 61 cases and uninfected group 192 cases according to pulmonary infection. The pathogens distribution and incidence of risk factors were analyzed in infection group, and the neurological deficit scores and treatment effect were observed and compared in two groups of patients before and after treatment. RESULTS There were 61 cases of lung infection happened in 253 patients with stroke, and the infection rate was 24.11%. A total of 71 strains of pathogens were detected, among which 49 strains were gram-negative bacteria, according to 69.01%, 18 strains of gram-positive bacteria, accounting for 25.35%, and 4 strains of fungi, accounting for 5.63%. Patients with cerebral infarction, dysphagia, hyperglycemia, disturbance of consciousness and chronic lung disease had significantly higher lung infection rate (P＜0.05). After treatment, the neurological deficit scores in infection group were significantly higher than uninfected group (P＜ 0.05); the mortality rate was 24.59% in the infection group, and the control group mortality rate was 8.85% and the differences were significant (P＜0.05). CONCLUSION The risk factors for stroke patients with lung infection are more than others, which should be paid enough attention to prevention in clinical treatment.