Abstract: OBJECTIVE To analyze the characteristics and risk factors of hand-foot-and-mouth disease (HFMD) in children hospital infections, and discuss the correlation factors of HFMD children with severe hospital infections and propose specific preventive measures for the treatment, so as to provide a scientific basis for the treatment of HFMD children. METHODS A total of 564 cases of children with HFMD got treatment in our hospital from Dec. 2012 to Dec. 2014 were selected for this study. Age of children, the complication, whether to use the breathing machine, whether indwelling stomach tube, use of hormones, whether or not combined with a variety of antibiotics and hospitalization time were all under analysis to understand the correlation between them and hospital infections and discuss the interventions. RESULTS There were 46 cases of children with hospital infections among 564 cases of children with HFMD, infection rate 8.16%. Most of the infection was respiratory infections accounted for 41.3%, followed by digestive infection, accounting for 34.8%. Children in low age, with complications, using breathing machine, whether indwelling stomach tube, invasive procedure, using hormones, combined with a variety of antibiotics had infection rate significantly higher, accounting for 24.6%, 24.0%, 20.0%, 23.2%, 16.1%, 11.7% and 14.8%. Prolonged hospitalization led to contact with more pathogens which easily to got infections. CONCLUSION About the treatment, children with severe HFMD should get early notice and treatment, with shorter hospitalization time, and less invasive procedures. Rational use of antibiotics and the implementation of optimization nursing intervention can control hospital infections positively and effectively.