Abstract: OBJECTIVE Interventional treatment from hair nerve distribution intracranial infection pathogens and drug sensitivity of the investigation and analysis,to provide reference evidence for clinical treatment.METHODS Select the hospital in August 2010- October 2015 nerve involvement after intracranial infection in patients treated845 cases,spinal puncture to obtain cerebrospinal fluid specimens using Vitek 2Compact type of bacteria identification.RESULTS 276 pathogens isolated were gram-negative bacteria 131,accounting for 47.46%,Acinetobacter baumannii 47（17.03%）,Klebsiella pneumoniae 28（10.14%）,Pseudomonas aeruginosa 21（7.61%）;grampositive bacteria 93,accounting for 33.69%,Staphylococcus aureus 32（11.6%）,Staphylococcus epidermidis 24（8.70%）;fungi 52,accounting for 18.84%,mainly Cryptococcus neoformans 46（16.67%）.Resistance rates of A.baumannii,P.aeruginosaand K.pneumoniae resistance rates to ampicillin,penicillin were 100.0%,and K.pneumoniae resistance rate to imipenem was 8.9% and 5.6%.Resistance rates of S.aureus and Staphylococcus epidermidis to penicillin,cefoxitin were 100.0%.C.neoformans did show resistance to voriconazole,fluconazole,amphotericin B.CONCLUSION Gram-negative bacteria are the main pathogens in neurology intervention in patients with intracranial infection,drug resistance to a variety of infections is higher.