Abstract: OBJECTIVE To investigate the correlation of pancreatic cancer incidence to blood types and hepatitis C virus infection, so as to provide a theoretical basis for guiding the prevention and treatment of pancreatic cancer. METHODS A retrospective analysis was taken to 60 cases of pancreatic cancer patients in hepatobiliary and pancreatic surgery of our hospital from May 2012 to Apr. 2015. Multivariate regression analysis was used for study the correlation between ABO blood types and hepatitis C virus infection to pancreatic cancer. RESULTS The type A, B, O and AB blood type of patients accounted for 30.00%, 28.33%, 30.00% and 11.67% in patients with pancreatic cancer. Patients with blood types A had correlation with the incidence of pancreatic cancer, and the difference was significant (OR=1.39, 95% Cl of 1.01~1.81, P<0.05); HCV antibodies were positive risk factors, history of diabetes, smoking history, history of alcohol abuse were all the high risk factors leading pancreatic cancer. CONCLUSION A-type blood and hepatitis C virus infection will increase the risk of pancreatic cancer.