Abstract: OBJECTIVE To study fungal distribution and sensitivity to drugs of cancer patients with oral infection , so as to provide reference about how to choose antifungal drugs in clinic. METHODS A total of 82 cases of cancer patients with fungal infections got treatment from department of stomatology in our hospital during Dec. 2014 to Dec. 2015 were selected and samples of these patients were collected to analyze fungal distribution and sensitivity to antifungal drugs by using SPSS 18.0 to give statistic analysis. RESULTS The departments of 82 cancer patients with oral infection were distributed widely, and the top three were department of geriatrics, ICU and endocrinology, accounting for 31.71%, 28.05 and 12.20% respectively. A total of 103 strains of fungi were isolated from the cancer patients with oral infection, and the top three were Candida, Candida tropicalis and Candida glabrata, accounting for 50.49%, 20.39% and 12.62%, respectively. Drug sensitivity rates of Candida, Candida tropicalis and Candida glabrata to amphotericin B were all 100.0%. CONCLUSION The fungi of cancer patients with oral infections is relatively complex, which should be given strengthened isolation and identification, and sensitive antibiotics should be used according to the drug sensitivity test.