Abstract: OBJECTIVE To investigate hospital-acquired pneumonia pathogens and drug resistance types of stroke patients, so as to provide the basis for the treatment of infected patients. METHODS Clinical data of 42 patients admitted to hospital with stroke and pneumonia from Jun. 2011 to Sep. 2014 were selected. Pathogens and their drug resistance were analyzed, and the data were analyzed by SPSS 11.0. RESULTS Totally 76 strains of pathogens were isolated from 42 patients sputum samples, including 57 stains of gram-negative bacteria (75.00%), 12 stains of gram-positive bacteria (15.79%), and 7 stains of fungi (9.21%). The drug resistant rates of Klebsiella pneumoniae to levofloxacin, imipenem, ciprofloxacin, cefixime, and tobramycin were less than 20.00%; Pseudomonas aeruginosa to gentamicin and tobramycin were 0.00%; Acinetobacter baumannii to ampicillin/sulbactam, levofloxacin, ciprofloxacin, and tobramycin were less than 20.00%; Staphylococcus aureus to tigecycline and vancomycin were 0.00%, to gentamicin, levofloxacin, and tobramycin were relatively low; Staphylococcus epidermidis to gentamicin, levofloxacin, vancomycin, and tobramycin were less than 30.00%; and Candida albicans to amphotericin B and fluconazole were 0.00%, to itraconazole was 25.00%. CONCLUSION Analysis of hospital-acquired pneumonia type infection pathogens and drug resistance in stroke patients has great guiding significance for clinical treatment.