Abstract: OBJECTIVE To analyze the clinical diagnosis and treatment of severe chest trauma complicated by chest infection, so as to provide reference for clinical treatment. METHODS A total of 96 patients with severe chest trauma complicated by chest infection in hospital from Feb. 2013 to Dec. 2015 were selected, who were randomly divided into observer group and control group. Control group patients were taken trentment of diagnosis and treatment of regulation, and observer group patients were taken trentment of Xuebijing injection. The treatment effects in two groups were compared. RESULTS Hospitalization time of observation group (12.2±6.3) d was significantly shorter than that in the control group (15.9±5.8) d (P<0.05). After treatment, both groups laboratory parameters were improved, observation group RR (19.2±4.3) times/min, CRP(12.6±4.2)mg/L, WBC(11.1±2.0)×10⁹/L significantly lower than those in the control group RR (22.0±4.3) times /min, CRP(15.1±2.2)mg/L, WBC (12.4±2.2)×10⁹/L (P<0.05). The total effective rate of clinical symptoms in observation group (98.0%), which was significantly higher than that in control group (68.8%) (P<0.05). CONCLUSION Conventional therapy combined Xuebijing therapy can improve the therapeutic effect of patients with severe chest trauma and chest infections, which has promotional value.