Abstract: OBJECTIVE To investigate the effect of the treatment of bone infection after trauma with the vancomycin-release system and Wright calcium sulfate, so as to provide the basis for the treatment of post traumatic and fracture resistance. METHODS A retrospective analysis was made on 67 cases of postoperative patients with bone infection in our hospital from Jan. 2012 to Aug. 2015, including 35 patients with vancomycin-release system and Wright calcium sulfate as study group, and 32 cases with sensitive antibiotics as control group. The infection clearance rate, fracture healing rate, healing time of fracture, and reoperation rate were compared between the two groups. RESULTS In study group, the clearance rate and healing rate of I infection, II infection were 80.00%,94.29% and 94.29%, which were significantly higher than 50.00%,75.00% and 75.00% of control group, and the reoperation rate was 20.00%, which was significantly lower than 50.00% of control group (P<0.05). The fracture healing time and bone healing time of study group were (4.1±0.4)d and(5.2±0.5)d, which were significantly shorter than (5.3±0.7)d and(6.8±0.8)d of control group (P<0.05). The lesions of the disease of the two groups of patients were mainly Staphylococcus aureus. CONCLUSION The cure rate and the healing rate of the treatment of the fracture internal fixation with the antibiotic delivery system are high, and it is worthy of clinical application.