Abstract: OBJECTIVE To investigate the distribution of hospital infection caused by carbapenem-resistant Acinetobacter baumannii (CRAB) in patients of department of cardiology, and analyzed the drug resistance, so as to provide theoretical guidance and basis for clinical rational use of antibiotics. METHODS A total of 2653 cases of hospitalized patients in the department of Cardiology from Jun,2011 to Jun. 2015 were selected as research subjects. The infection rate of CRAB was calculated, pathogen types were identified, and the drug resistance was analyzed. The data were analyzed by SPSS 19.0.. RESULTS There were 240 strains of CRAB and 312 cases of non-CRAB detected in the 2653 cases of hospitalized patients admitted to department of cardiology, accounting for 9.04% and 11.76%. The main infection sites were respiratory system, digestive system, urinary system, and skin, accounting for 56.67%, 15.00%, 10.00%,10.00%, respectively. By comparison of the drug resistant rates of CRAB and non-CRAB to 15 kinds of commonly used antibiotics, except cefotaxime and ceftriaxone, the drug resistant rates of CRAB to 13 kinds of antibiotics were significantly higher than those of non-CRAB, and the drug resistant rates of two types of pathogens had significantly difference (P<0.05). CONCLUSION The incidence of respiratory infections in patients with CRAB in the department of cardiology is high, which has strong resistance to most of the antimicrobial agents. In the course of clinical treatment, it should be timely detection of pathogenic bacteria and their drug resistance, rational application of antibacterial drugs for pulmonary infection prevention, control and treatment, so as to reduce the incidence of drug resistant bacteria.