Abstract: OBJECTIVE To investigate the risk factors of sequelae prognosis in children with purulent meningitis combined infection,so as to provide a basis for clinical practice.METHODS A total of 148 cases of children’s clinical data with purulent meningitis combined infection sequelae from Sep.2014 to Oct.2015 in our hospital were selected and analyzed,according to the prognosis the children were divided into control and experimental groups.The control group had 30 cases of children with poor prognosis,and the test group had 118 cases of children with good prognosis,using self questionnaire to two groups of children to give univariate and multivariate unconditional logistic regression analysis.RESULTS The test group of cerebrospinal fluid protein content,procalcitomin was significantly lower than the control group（P＜0.05）.Cerebrospinal fluid glucose concentration,platelet count was significantly higher than the control group（P＜0.05）.Single factor analysis showed that the clinical adverse effects convulsions,coma（Glasgow score＜8）,meningeal irritation and repeated vomiting more than 3times had no significant difference with children with purulent meningitis complicated with infection sequela,but anisocoria,cerebrospinal fluid glucose≤1.5 mmol/L,limb movement disorder and hospitalization time ＞21days had close relation with the sequela（P＜0.05）.Multi-factor logistic results showed that anisocoria,cerebrospinal fluid glucose≤1.5mmol/L,cerebrospinal fluid protein＞1 000mg/L and hospitalization time＞21days had close relation to children with purulent meningitis complicated with infection sequela bad prognosis（P＜0.05）.CONCLUSION Children purulent meningitis combined infection sequelae has many relatively impact factors,which should propose specific measures based on risk factors to improve clinical outcomes.