Abstract: OBJECTIVE To discuss distribution of pathogenic bacteria and immune function status in children patients with recurrent respiratory tract infections(RRI), in order to assist in clinical treatment and reduce infection rate. METHODS From Jan.2014 to Dec.2015, 54 patients with RRI in our hospital were included in observation group, and another 50 healthy children were selected as control group in the hospital. The distribution of pathogenic bacteria(CD₃⁺、CD₄⁺、CD₈⁺、CD₄⁺/CD₈⁺),cellular immune parameters(immunoglobulin of IgA, IgM, IgG, complement of C₃,C₄), humoral immune parameters and cytokine levels(IL-4,IL-10, IL-12) were compared. RESULTS Totally 103 strains of pathogens were detected in children ≤ 5 years old, mainly Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus, accounting for 17.48%,16.50%,and 15.53%, respectively. Totally 117 strains of pathogenic bacteria were detected in children >5 years old, mainly E.coli,K.pneumoniae,and S.aureus,accounting for 17.09%,15.38%,and 14.53%, respectively. There was no significant difference in the infection rate between ≤ 5 and > 5 years old children. The CD₃⁺ and CD₄⁺/CD₈⁺ in observation group were significantly lower than those in control group,CD₈⁺ was significantly higher than that in control group(P<0.05).The IgM,IgG and C₃ of observation group were significantly lower than those of control group (P< 0.05).The IL-4 and IL-10 of observation group were significantly higher than those of control group, while IL-12 was significantly lower than that of control group (P<0.05). CONCLUSION The cellular immunity and humoral immune function in children with RRI were relatively low, the level of inflammatory factors in abnormal condition and the pathogenic bacteria of repeated infection were mainly E. coli and K.pneumoniae. Clinical treatment should focus on monitoring the symptoms of infections, so as to give better treatment.