Abstract: OBJECTIVE To learn the distribution and drug sensitivity of pathogenic bacteria from patients with diabetic nephropathy complicated with foot infection, so as to provide research basis for the clinical diagnosis and rational use of drugs of the disease. METHODS A total of 115 cases of patients with diabetic nephropathy complicated with foot infection from Jan. 2013 to Dec. 2015 were chosen. Superficial wound and deep abscess cavity of foot specimens were collected, strain kinds of specimens were identified, and drug susceptibilities of the main pathogenic bacteria were tested. RESULTS Totally 157 strains of pathogenic bacteria were isolated from 143 specimens of the 115 cases of patients, and the pathogenic bacteria primarily were gram-positive bacteria, was accounting for 57.86%. Totally 14 strains of MASA were detected from 39 strains of Staphylococcus aureus, and the positive rate of MRSA was 35.90%. Eight ESBLs-producing strains were detected from 28 strains of Escherichia coli, accounting for 28.57%. Sensitive rates of S. aureus and Enterococcus faecalis to linezolid and vancomycin were both 100.00%. CONCLUSION By monitoring the distribution, changes and susceptibility characteristics of pathogens, rational antimicrobial application solutions can be established, and it is beneficial for the treatment of diabetic nephropathy complicated with foot infection.