Abstract: OBJECTIVE To explore the value of detection of serum procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (IL-6) in diagnosis of postoperative early infections in patients with limbs closed fractures. METHODS A total of 5 800 patients with limbs closed fractures who received surgical procedures from Jan 2010 to Mar 2010 were enrolled in the study and divided into the infection group with 62 cases and the non-infection group with 5 738 cases according to the status of infections.The venous blood samples were respectively collected after the surgery for 1, 3, 5, and 5 days; the changes of levels of PCT, CRP, and IL-6 were observed. RESULTS The level of PCT of the non-infection group was significantly lower after the surgery for 7 days than after the surgery for 1 day; the levels of CRP and IL-6 of the non-infection group were significantly lower after the surgery for 3, 5, and 7 days than after the surgery for 1 day(P＜0.05).The levels of PCT, CRP, and IL-6 of the infection group were significantly higher after the surgery for 3, 5, and 7 days than after the surgery for 1 day(P＜0.05).The levels of PCT, CRP, and IL-6 of the infection group were significantly higher than those of the non-infection group after the surgery for 3, 5, and 7 days(P＜0.05).The sensitivity of the joint detection of PCT, CRP, and IL-6 was higher than that of the single detection of PCT, CRP, or IL-6. CONCLUSION The serum PCT, CRP, and IL-6 are the important detection indicators for diagnosis of postoperative early infections in the patients with limbs closed fractures; the joint detection of the three indicators can raise the sensitivity of diagnosis, and it is worthy to be promoted in the hospital.