Abstract: OBJECTIVE To explore the clinical efficacy of oxygen atomization inhalation in treatment of bulbar paralysis patients complicated with pulmonary infections so as to provide guidance for clinical treatment. METHODS A total of 80 bulbar paralysis patients complicated with pulmonary infections who were treated in hospitals from Feb 2011 to Feb 2016 were enrolled in the study and divided into the observation group and the control group according to the treatment method, with 40 cases in each group.The control group was treated with conventional symptomatic therapy, while the observation group was given oxygen atomization inhalation therapy based on the conventional symptomatic therapy.The status of clinical treatment was observed and compared between the two groups of patients. RESULTS The effective rate of treatment of the observation group was 87.5%, significantly higher than 67.5% of the control group(P＜0.05).As compared with the control group, the sputum volume of the observation group was remarkably decreased, the characteristics of sputum, breath sounds, and sleep quality were remarkably improved(P<0.05). CONCLUSION The oxygen atomization inhalation can achieve significant clinical efficacy in treatment of the bulbar paralysis patients complicated with pulmonary infections, remarkably reduce the sputum volume, and improve the breath sounds as well as the sleep quality; it is worthy to be promoted in the hospital.