Abstract: OBJECTIVE To explore the influence of changes of procalcitonin (PCT), C-reactive protein (CRP), and peptide levels on prognosis of hypertensive cerebral hemorrhage patients complicated with pulmonary bacterial infections so as to provide guidance for clinical treatment. METHODS Totally 68 hypertensive cerebral hemorrhage patients complicated with pulmonary infections who were treated in the hospital from Jan 2012 to Jan 2015 were assigned as the group A, meanwhile, 68 hypertensive cerebral hemorrhage patients without pulmonary infections were set as the group B, and 68 healthy people who received physical examination were assigned as the group C.The group B was given conventional conservative therapy, the group A was treated with antibiotics based on the treatment of the group B.The levels of PCT, CRP, and peptide as well as white blood cell (WBC) counts were observed and compared among the three groups before the treatment and after the treatment for 7 days; the positive rates of the indicators were observed and compared between the group A and the group B before and after the treatment. RESULTS The levels of the indicators of the group A were higher before the treatment than after the treatment and were higher than those of other two groups before and after the treatment (P＜0.05).The levels of PCT, CRP, and peptide of the group B were lower after the treatment than before the treatment and were higher than those of the group C (P＜0.05).The PCT more than 0.5 ng/L, CRP more than 10 mg/L, peptide more than 0.01 ng/ml, WBC more than 10×10⁹/L, and N% more than 70% were defined as the positive; the positive rates of PCT, CRP, and peptide of the group A were lower after the treatment than before the treatment and were higher than those of the group B (P＜0.05).Totally 23 patients with infections in the group A died within 30 days, with the mortality rate 33.82%; the levels of PCT, CRP, and peptide of the patients who survived were lower than those of the patients who died (P＜0.05). CONCLUSION The PCT, CRP, and peptide can be used as the predictive indicators for the complicated pulmonary infections in the hypertensive cerebral hemorrhage patients and provide guidance for clinical treatment, which can be used as the indicators for prediction of the prognosis.