Abstract: OBJECTIVE To explore the effect of evidence-based management on control of infections in operating rooms so as to reduce the infection rate in operating rooms. METHODS The related data of prevalence of infections and environmental monitoring of the operating rooms were collected from Jan 2014 to Dec 2014, the clinical data were collected from Jan 2015 to Dec 2015 after the evidence-based management was conducted, and the comparative analysis of the two groups of data was performed with the use of SPSS17.0 software. RESULTS The infection rate was 9.39% in the operating rooms before the evidence-based management was conducted (2014) and was 3.60% after the evidence-based management was conducted (2015), and there was significant difference between the two (P＜0.05).The qualified rates of nosocomial infection monitoring of five aspects, object surfaces, healthcare workers' hands, air, ultraviolet lamps, and disinfectants in use, were significantly higher after the evidence-based management was implemented than before the evidence-based management was implemented, and there was significant difference between the two (P＜0.05). CONCLUSION The evidence-based management has positive effect on reduction of incidence of postoperative infections in the surgery patients, effectively improve the environment of the operating rooms, and raise the patients' satisfaction; it is worthy to be promoted in the hospital.