Abstract: OBJECTIVE To analyze the epidemiological characteristics of nosocomial infections caused by carbapenem-resistant Acinetobacter baumannii (CRAB) in a three-A general hospital so as to provide guidance for control of the CRAB infections. METHODS The patients with CRAB infections who were hospitalized in a three-A general hospital from Jan 1, 2005 to Dec 31, 2014 were enrolled in the study, then the epidemiological characteristics, including the population, time, and departments, were analyzed by means of the unified diagnostic criteria and methods. RESULTS Of totally 508 332 hospitalized patients who were investigated, 252 had the CRAB infections, with the infection rate 0.50‰; the incidence of CRAB infections was higher in the male patients than in the female patients; the incidence of nosocomial infections was higher in the elderly patients than in the non-elderly patients.The CRAB infections showed certain seasonal characteristics, the incidence of CRAB infections was 0.73‰ in the first quarter, 0.53‰ in the fourth quarter, and it was in accordance with the seasons of high prevalence of respiratory tract diseases.As for the distribution of departments, the incidence of nosocomial infections was higher in the hospitalized patients of ICUs than in the hospitalized patients of common wards; the infection rate was higher in the hospitalized patients of internal medicine department than in the hospitalized patients of surgery departments.Of the patients with CRAB infections, 75.79% had respiratory tract infections. CONCLUSION The male and elderly patients are the populations at high risk of CRAB infections, and the ICU is the key department where the CRAB infection is prevalent.It is necessary to strengthen the prevention and control of the CRAB infections in the key populations and departments.