Abstract: OBJECTIVE To prevent and control bloodstream infections by using personalized risk assessment form. METHODS The personalized risk assessment form was developed by using risk assessment method, then the randomized controlled trial was conducted for 118 patients, 61 patients were assigned as the critical care medicine group 1 ( the experimental group), 57 patients were set as the critical care medicine group 2 (the control group), the observation endpoint was set at the discharge of the department for 48 hours, the incidence of bloodstream infections was served as the measurement indicator, the clinical performance in prevention and control of the bloodstream infections was observed and compared between the two groups of patients, and the risk assessment program was further improved. RESULTS There was significant difference in the effect of the personalized risk assessment form on prevention and control of bloodstream infection between the experimental group and the control group (χ²＝37.21,P<0.05). CONCLUSION The personalized risk assessment form can intervene in high-risk projects through prediction of infection so as to prevent the bloodstream infection, however, the form is developed based on the blueprint of general hospitals, and there might be certain deviation when it is promoted in specialized hospitals.