Abstract: OBJECTIVE To understand the characteristics of nosocomial infection management in unexpected mass traumatic events during medical rescue and raise the rate of successful rescue. METHODS The onsite survey was conducted for the rescue of 6 patients with critical explosion injuries who were treated in the ICU on May 22, 2014, then the specific, feasible, and effective control measures were put forward based on the actual situation and were adjusted based on the changes of injuries. RESULTS Of the 6 patients with critical explosion injuries who were treated in the ICU, 3 used ventilators, 3 received endotracheal intubation, 4 received urinary catheter indwelling, and 5 received deep venous catheter indwelling.The utilization rate of invasive procedures was no less than 50.0% among the 6 injured patients, and 2 cases were with the catheter indwelling time more than 10 days.The nosocomial infection occurred in 1 of 6 injured patients, with the infection rate 16.67%.The type of the infection was ventilator-associated pneumonia caused by multidrug-resistant Acinetobacter baumannii.All of 6 injured patients were rescued successfully and discharged. CONCLUSION It is an effective way to take all-around, scientific, and effective control measures so as to control the nosocomial infections in the critically injured patients in unexpected mass traumatic events.