Abstract: OBJECTIVE To investigate the infection situation, risk factors and drug resistance for children with Acinetobacter baumannii in the hospital, so as to provide basis for the prevention of children with A. baumannii infection. METHODS A total of 3222 cases of patients in the department of pediatrics of the hospital from Dec. 2012 to Dec. 2015 were chosen as research objects. The pathogens were isolated, cultured and identified, and the detected A. baumannii were taken for susceptibility test. The data were analyzed by SPSS 19.0. RESULTS Totally 471 strains of pathogens were cultured in the 3222 cases of children samples, and mainly were 278 strains of gram-negative bacteria, accounting for 59.02%. A. baumannii was the main pathogen, accounting for 16.56%. The risk factors for children with A. baumannii infection were mechanical ventilation, endotracheal intubation, usage time of antibiotics and catheter indwelling (P＜0.05). The resistant rate of A. baumannii to aztreonam was 97.44%, which is the highest. CONCLUSION A. baumannii is the most important cause of pediatric infectious, it has a higher resistant rate to aztreonam, and a lower resistance rate to imipenem, so we should guide the implementation of clinical diagnosis and treatment based on the results.