Abstract: OBJECTIVE To investigate the effect of intranasal infusion of miconazole on non-invasive fungal sinusitis after endoscopic sinus surgery, in order to provide evidence for the clinical treatment of non-invasive fungal sinusitis. METHODS A total of 135 cases of patients intends to carry out nasal endoscopic treatment of non-invasive fungal sinusitis from Jan. 2010 to Dec. 2015 were selected, and were divided into observation group (69 cases), control group (66 cases) by blind randomized method. Patients in the two groups were given endoscopic surgical treatment, in control group, were given the postoperative 5D, 15d endoscope cleaning cavity operation, and in the observation group were given miconazole sinus perfusion based on the treatment of control group, and both of the two groups did not use anti-infective drugs. The recurrence rates of the two groups of patients with recovery were observed. RESULTS The CRP of observation group after treatment was lower than the same group before treatment and control group after treatment (P<0.05). The PCT of the two groups before and after treatment had no statistically significant difference. The two groups were followed up for 1 years, and the recurrence rates of observation group were lower than those of control group in 6 and 12 months (P<0.05). CONCLUSION The curative effect of miconazole sinus perfusion and no antibiotics for nasal endoscopic treatment of non-invasive fungal sinusitis is satisfactory, and the recurrence rate is low, which is worthy of the clinical promotion, but the value of CRP in the treatment has to be further studied.