Abstract: OBJECTIVE To investigate the effects of combined analgesia and peripheral joint intervention on postoperative infection and pain in elderly patients with joint replacement, so as to provide references for postoperative analgesia and infection. METHODS A total of 196 cases of patients undergoing joint replacement surgery from Jan.2013 to Dec.2015 were selected, and were divided into observation group (100 cases) and control group(96 cases) according to random single-blind method. Patients in observation group were given postoperative patient-controlled epidural analgesia combined with Cocktail analgesia, and in control group were given postoperative patient-controlled intravenous analgesia combined with local injection analgesia The degrees of joint motion were observed at 1, 3, 7 and 14d after operation. RESULTS During the treatment, there were no significant differences of infection rates of various sites between the two groups, and there had a significant difference of total infection rate between the two groups (P<0.05). After 1, 3, 7, 14 days of operation, the joint activity of the two groups increased gradually with time(P<0.05). The postoperative complications of the two groups had no significant difference. CONCLUSION Patient-controlled epidural analgesia and local injection analgesia combined with postoperative intervention in elderly patients undergoing joint replacement surgery can reduce the incidence of postoperative infection, reduce postoperative pain, and improve joint mobility, and it is worthy of clinical promotion.