Abstract: Making dental impressions is a fundamental and key link in prosthodontics. The development of the traditional dental impression technique has a history of more than 100 years. Since the dental impressions get in direct contact with saliva or even the blood of the patients, they might be contaminated by pathogenic bacteria and be the media for spreading disease without disinfection. The disinfection methods and the effects of the disinfectants on the three dimensional accuracy and property of the impressions,has always been the hot spots of the dentists. In recent years, the evolution of digital impression technology for oral prosthodontics has opened up a new digital field, and the advantages of precision, velocity and economy make it favored by dentists. This review summarized the current methods of disinfection and the influence on the property of the dental impressions, and the advancement and future perspectives of digital impression.