Abstract: OBJECTIVE To investigate clinical MRI and CT imaging characteristics of intracranial fungal infection to improve the accuracy of diagnosis, and maximumly avoid the deterioration caused by misdiagnosis. METHODS A total of 80 patients with intracranial fungal infection diagnosed by pathology from Jan. 2008 to Dec. 2016 were selected, and their characteristics were analyzed and summarized by analyzing CT and MRI imaging characteristics. RESULTS CT imaging of fungal granuloma or abscess was mostly high-density or mixed density, MRI scans showed T1W1 low signal, and the signal changes of T2W1 were large, predominantly in signal level or slightly lower. Fungal meningitis involving extensive brain base pool CT imaging showed decreased basal cell density and shallower cerebral sulcus, MRI scan showed a significantly higher signal of T2W1, and T1W1 exhibits, etc, or slightly lower signal. CONCLUSION Intracranial granuloma T1W1 low signal content and meningitis T2W1 were significantly higher signal may be characteristic features of fungal infections.