Abstract: OBJECTIVE To analyzed the status quo of catheter-related urinary tract infection in the intensive care unit patients, so as to formulate the corresponding prevention interventions. METHODS A total of 1596 patients with indwelling catheter from Jan.2012 to Dec.2015 were selected. The clean middle urine of the patients early in the morning were collected for drug sensitivity analysis, and the risk factors and intervention measures of urinary tract infection in patients were analyzed. RESULTS There were 72 cases of patients occurred catheter-related urinary tract infection, with the infection rate of 4.5%. Totally 126 strains of pathogenic bacteria were detected, and mainly were 62 strains of fungi, accounting for 49.2%. The multiple factors logistic analysis showed that, age >60 years old, female, diabetes mellitus, prostatic hyperplasia, kidney stones, urethral opening cleaning <7 times per week and catheter indwelling time ＞ 7 d were independent risk factors for catheter-related urinary tract infection in ICU patients. CONCLUSION The fungal infection rate in ICU patients with catheter-related urinary tract infection is high. It should take appropriate intervention measures in clinical according to risk factors of ICU urinary tract infection, and guide clinical medication according to susceptibility testing.