Abstract: OBJECTIVE To study the epidemiological characteristics of nosocomial infections in patients with acute myocardial infarctions, and analyzed the risk factors and countermeasures, in order to provide references for the prevention of nosocomial infections in patients with acute myocardial infarction. METHODS The general demographic data, incidence of nosocomial infections, and epidemiological characteristics of 317 cases of patients with acute myocardial infarction from Dec. 2013 to Sep. 2015 were investigated by using cross-sectional study method. Univariate and multivariate analysis were used to analyzed the risk factors which according to the characteristics of infection for nosocomial infections in patients with acute myocardial infarction. RESULTS A total of 37 patients and 41 cases occurred nosocomial infections in 317 patients with acute myocardial infarction, with the incidence of nosocomial infections of 11.67%. Respiratory tract was the main infection site, with the occurrance of 25 cases, accounting for 60.98%. Univariate analysis showed that age, length of hospital stay, diabetes, chronic obstructive pulmonary disease, heart function class, preventive use of antibiotics, etc. were the risk factors of nosocomial infections. Unconditional logistic regression analysis showed that the independent risk factors for acute myocardial infarction were age more than 60 years old, hospitalization days more than 7 days, diabetes mellitus, chronic obstructive pulmonary disease, and cardiac function class Ⅲ to Ⅳ. CONCLUSION The risk factors of nosocomial infections in patients with acute myocardial infarction are elderly, combined with basic diseases, cardiac function and so on, and preventive measures should be taken to reduce the incidence of nosocomial infections in these people.