菌血症患者血浆内毒素测定及病原菌分析

Plasma endotoxin detection and bacterial species analysis for patients with bacteremia

    摘要
  • 摘要: 目的 通过分析菌血症患者血浆内毒素及病原菌类型,为临床判断病原菌种类及治疗提供参考依据。方法 选取2015年1月-2016年4月医院菌血症患者97例,根据内毒素和血培养结果分为组1(G-+ET+)、组2(G-+ET-)、组3(G-)、组4(ET+)及组5(菌血症组);比较不同菌种在五组间内毒素水平,数据采用SPSS 22.0软件进行统计分析。结果 肠杆菌和非肠杆菌在(G-+ET-)组和(ET+)组间(P=0.04)、(G-+ET-)组和菌血症组间(P=0.00)、(G-)组和菌血症组间(P=0.00)的分布不同;菌血症组、(G-)组的白细胞计数(WBC)随着内毒素水平的升高而升高。结论 应用鲎试验定量比浊法检测内毒素有助于对早期菌血症、内毒素血症、革兰阴性菌败血症患者感染的细菌种类做出判断。

     

    Abstract: OBJECTIVE To analyze the plasma endotoxin and bacterial species in patients with bacteremia, so as to provide scientific basis for the clinical diagnosis of bacterial species and treatment. METHODS Totally 97 bacteremia patients were recruited in the study from Jan. 2015 to Apr. 2016 and divided into five groups according to endotoxin and blood culture results: (G-+ET+) group,(G-+ET-) group,(G-) group,(ET+) group and bacteremia group. The distribution and different plasma endotoxin levels of various species among the five groups were compared. The data were analyzed by SPSS 22.0 software. RESULTS The distributions of Enterobacter and non-Enterobacter were different between (G-+ET-) group and (ET+) group (P=0.044), (G-+ET-) group and bacteremia group (P=0.000), and (G-) group and bacteremia group (P=0.000), respectively. WBC of bacteremia group and (G-) group were increased with the increase of endotoxin level. CONCLUSION Application of limulus test quantitative turbidimetric assay of endotoxin helps to determine the bacterial species of patients with early bacteremia, endotoxemia, and gram-negative bacteremia.

     

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