Abstract: OBJECTIVE To investigate the drug resistance status and the distribution of methicillin-resistant Staphylococcus aureus (MRSA) among elderly patients in hospital , assess the result of the control of hospital infection, so as to provide basis for the reasonable clinical application of antibiotics. METHODS The drug sensitivity and clinical data of 281 cases of MRSA were collected from 2013 to 2015,these strains were identified by MicroScan-autoSCAN4 semi automatic bacteria identification instrument. The statistical results were analyzed by WHONET 5.6 software. RESULTS The number of identification of MRSA was decreased in turn, from 104 in 2013 to 79 in 2015. In all specimens of inspection, the highest rate of isolation of MRSA was 44.48% from the sputum specimens, and there was not findiy of MRSA in blood specimens. Drug sensitivity analysis showed that MRSA was completely resistant to penicillin G and oxacillin. CONCLUSION The rate of identification of MRSA is higher in elderly patients. Centralized management in critically ill patients, reasonable and effective use of antibiotics and timely adjustment of medication are conducive to the control of MRSA infection.