Abstract: OBJECTIVE To investigate the changes of serum levels of inflammatory cytokines and relationship between immune function and myocardial function in patients of heart failure with pulmonary infection, so as to provide references for clinical diagnosis and treatment of heart failure with pulmonary infection. METHODS A total of 55 patients of heart failure with pulmonary infection in the hospital from Dec. 2014 to Aug. 2015 were chosen as infection group, and another 55 patients of heart failure without pulmonary infection were chosen as non-infection group. The clinical indexes of the two groups were compared. RESULTS The BNP, IL-6 and TNF-α of infection group were (453.45±32.94) ng / L, (2.73±1.53) ng/L, (29.46±5.35) ng/L, which were all higher than those of non-infection group. The LVEF of infection group was (44.62±2.28)%, which was lower than that of non-infection group. The LVEDV and LVESDVI levels of infection group were higher than those of non-infection, and the differences were significanct (P<0.05). CONCLUSION The pulmonary infection can lead to the increase of the serum levels of inflammatory cytokines and the exacerbating of injury of immune function and myocardial function, thereby increasing the patient's condition.