Abstract: OBJECTIVE To investigate the relationships between the depth of infections, C-reactive protein (CRP), tumor necrosis factor-alpha(TNF-ɑ), interleukin-6(IL-6) and immune protein levels with lower extremity vascular disease (PAD) degree in patients with diabetic foot bacterial infections, in order to provide the data basis for finding the relationships between them. METHODS A total of 435 cases of patients with diabetic foot bacterial infections in hospital from Jan. 2010 to Dec. 2015 were selected, and were divided into combined group of 213 cases and uncombined group of 222 cases according to whether complicated with PAD. The PAD degree and depth of infection division of the two groups of patients were measured after admission, and the inflammatory factors and immune factors levels were determined on the following day. The levels of inflammatory factors and immune factors were observed in two groups of patients with different infection depths and different PAD levels. RESULTS The PAD degree was higher with deeper infection in patients of combined group(P<0.05), which was significantly higher than the patients of uncombined group with the same level (P<0.05. The PAD degree was higher with higher levels of inflammatory factors in the two groups(P<0.05), and combined group was higher than that in uncombined group with the same inflammatory factor index and same level of PAD(P<0.05), and the PAD degree was higher with lower levels of immune factors in the two groups(P<0.05), and combined group was higher than that in uncombined group with the same immune factors and same level of PAD(P<0.05). CONCLUSION The depth of infections, inflammatory factor CRP, TNF-ɑ, IL-6 and immune protein levels were associated with PAD in patients with diabetic foot bacterial infections.