Abstract: OBJECTIV To explore the effective drug dressing approaches for patients undergoing anterior ear fistula infection abscess incision surgery so as to provide guidance for postoperative drug dressing for the patients undergoing the anterior ear fistula infection abscess incision surgery. METHODS A total of 138 patients who underwent the anterior ear fistula infection abscess incision surgery in the otology department from Dec 2012 to Dec 2013 were enrolled in the study and divided into the study group (thorough debridement and pus drainage ) and the control group (incision and pus drainage) according to the clinical drug dressing approach, with 69 cases in each group. The clinical efficacy, incidence rate of adverse reactions, healing time, and treatment cost were observed and compared between the two groups of patients. RESULTS The cure rate of the study group was 55.07%, higher than 33.33% of the control group; the total effective rate of the study group was 94.20%, higher than 79.71% of the control group, and there was significant difference (P<0.05). The incidence rates of infection, red swelling, and pain of the study group were respectively 8.70%, 13.04%, and 10.14%, lower than 26.09%, 39.13%, and 37.68% of the control group, and there was significant difference (P<0.05). The healing time of the study group was (9.23±1.93)days, shorter than (14.34±2.98)days of the control group; the treatment cost of the study group was (160.34±10.34) yuan, less than (210.34±22.64)yuan of the control group, and there was significant difference (P<0.05). CONCLUSION The thorough debridement and pus drainage has obvious advantages for the patients undergoing the anterior ear fistula infection abscess incision surgery, and it is one of the ideal approaches for clinical practice owning to the good therapeutic effect, low incidence of postoperative adverse reactions, and little treatment cost.