Abstract: OBJECTIVE To investigate the effects of gamma globulin on myocardial injury, cardiac function and serum immunological indexes in patients with severe myocarditis, so as to provide references for clinical treatment. METHODS A total of 72 cases of severe myocarditis patients were divided into control group and study group according to digital table method, with 36 cases in each group. Patients in control group were treated with traditional method, while in study group were treated with traditional method combined with gamma globuli. The clinical indexes and efficacies of the two groups were compared. RESULTS The BNP, CK-MB and cTnT levels of 4 weeks after treatment of the two groups were all much less than before treatment respectively (P<0.05). The BNP, CK-MB and cTnT of 4 weeks after treatment of study group were less than those of control group (P<0.05). LVEF and LV of 4 weeks and 3 months after treatment of study group were all better than those of control group, with significant differences (P<0.05). The total effective rate of control group was 80.6%, which was much less than 94.4% study group (P<0.05). CONCLUSION The anti-inflammatory and antiviral effects of gamma globulin can reduce the severity of myocarditis on the heart damage, protect myocardial cells of patients, rapidly eliminate the virus in vivo, and improve clinical performance, which is worthy of clinical promotion.