Abstract: OBJECTIVE To explore the value of serum C-reactive protein (CRP) and procalcitonin (PCT) in assessment of severity and prognosis of diabetic foot infection so as to provide guidance for clinical treatment. METHODS A total of 177 patients with diabetic foot infection who were treated in the hospital from Jan 2014 to Dec 2015 were recruited as the study objects and divided into the group A ( the mild infection group ) wit 48 cases, the group B ( the moderate infection group ) with 99 cases, and the group C ( the severe infection group) with 30 cases according to the severity of the infection; the enrolled patients were divided into the cured group, the improved group, and the ineffective group according to the curative effect of diabetic foot. The levels of serum CRP and PCT were determined. RESULTS The levels of serum CRP and PCT were lower in the group A than in the group B and the group C (P<0.05); the levels of serum CRP and PCT were lower in the group B than in the group C (P<0.05); the levels of serum CRP and PCT of the three groups were remarkably lower after the treatment than before the treatment (P<0.05). The levels of serum CRP and PCT were lower in the cured group than in the improved group and the ineffective group after the treatment (P<0.05); the levels of serum CRP and PCT were lower in the improved group than in the ineffective group (P<0.05). CONCLUSION The levels of serum CRP and PCT are elevated with the increase of severity of diabetic foot infection and decline with the improvement of illness condition. The serum CRP and PCT have certain clinical value in assessment of severity and prognosis of the diabetic foot infection.