Abstract: OBJECTIVE To analyze and explore the effect of PDCA (Plan-do-check-act) cycle on control of the hospital infection management quality, so as to provide the basis for clinical infection control. METHODS PDCA was used in hospital infection management from Jul. to Dec. 2015. A total of 70 cases of Infection Control Branch and a member of the hospital medical staff involved in hospital departments were selected. The hospital infection management quality before and after 6 months of application of PDCA cycle management program were compared. RESULTS From Jan. to Jun. 2015, 38 cases of infection occurred in 2412 cases of patients, with the infection rate of 1.55%. From Jan. to Jun. 2016, after the implementation of PDCA cycle management, 14 cases of infection occurred in 2585 cases of patients, with the infection rate of 0.54%, and the hospital infection rate was significantly decreased after the implementation (P<0.05). PDCA The hand hygiene qualified rate and examination result qualified rate were 77.08% and 81.48% before the implementation of PDCA cycle management, and were 93.41% and 96.43% after the implementation of PDCA cycle management, which were significantly increased (P<0.05). The numbers of colonies were significantly decreased and the sterilization rates were significantly increased of blood collection units, color Doppler ultrasound machine and diagnostic instruments after the implementation of PDCA. The qualified rate of air culture rate 99.21% after the implementation of PDCA, which was significantly higher than 93.65% before the implementation of PDCA (P<0.05). CONCLUSION PDCA cycle can effectively improve the quality of management, reduce hospital infection rates and improve the quality of hospital disinfection, which is worthy of clinical promotion.