Abstract: KPC-producing Enterobacteriaceae is a species of multidrug-resistant gram-negative bacilli, it outbreaks and prevails worldwide, which results in extremely high mortality rate. At present, few antibiotics were available for clinical treatment of such infection, the efficacy of monotherapy is not satisfied, and the reports about the drug resistance are increased. Therefore, many clinicians embrace combination regimens as the preferred treatment strategy for the infection. In this review, we briefly discussed the disadvantages of antibiotics monotherapy on treatment of the KPC-producing Enterobacteriaceae and introduced the progress of study on in vitro antibacterial activities of different antibiotics combinations, it is suggested that the antibiotic combination therapy is superior to the monotherapy and that the combinations containing polymyxin and tigecycline are most commonly used and most effective, and the review concludes by recommending treatment schemes regarding relevant guidelines so as to provide certain guidance for clinical treatment of such infection.