Abstract: OBJECTIV To investigate the influence of different ages and surgical sites on postoperative pulmonary infections in patients with general anesthesia combined with epidural anesthesia, so as to provide a reference for prevention and control of postoperative pulmonary infections. METHODS A total of 300 cases of patients with general anesthesia combined with epidural anesthesia from Aug. 2015 to Aug. 2016 were selected. The postoperative pulmonary infections of patients was observed. RESULTS Totally 32 cases of postoperative pulmonary infections occurred in 300 patients, with the pulmonary infection rate of 10.67%. The infection rates were 3.35% of 18~60 year-old patients, 15.63% of 61~80 year-old patients, 55.63% of ＞80 year-old patients, and the difference was significant (P<0.05). There were significant differences in the infection rates among different age groups (all P<0.05). The pulmonary infection rate were 21.92% of thoracic surgery patients, 10.78% of epigastrium surgery patients, 4.00% of lower abdominal surgery patients, and the difference was significant (P<0.05). There were significant differences in the infection rates among different surgical sites groups (all P<0.05). CONCLUSION The age and surgical site have effects on postoperative pulmonary infections in patients with general anesthesia combined with epidural anesthesia. The old age and chest surgery are high risks of postoperative pulmonary infections.