Abstract: OBJECTIVE To compare infection characteristics of CRRT with APD in the treatment of AKI after cardiac surgery, so as to provide a references for anti-infective treatment of AKI. METHODS The clinical data of 128 patients with AKI after cardiac surgery from Mar. 2013 to Mar. 2016 were retrospectively analyzed, and were divided into CRRT group(58 cases) and APD group (70 cases) according to treatment methods. The infection rates of the two groups were recorded, and the infection characteristics were analyzed. RESULTS The infection rate of CRRT group was 16.46%, and the main detected specimen was incision secretions(36.73%). The infection rate of APD group was 18.14%, and the main detected specimen was dialysate(36.59%). The difference of infection rate was not significant between the two groups. Totally 42 pathogens were detected from CRRT group, including gram-positive bacteria(59.52%),gram-negative bacteria (33.33%),and fungi(7.14%), and 55 pathogens were detected from APD group, including gram-positive bacteria (65.45%),gram-negative bacteria (30.90%),and fungi(3.64%). The gram-positive bacteria had the sensitive rates of 100.00% to vancomycin and linezolid, and had high drug resistance to cefazolin and ampicillin. Gram-negative bacteria had the sensitive rates of 100.00% to imipenem and meropenem,and had high drug resistance to ceftriaxone, levofloxacin, and ampicillin. The dosages of vancomycin, teicoplanin, meropenem, and imipenem used in CRRT group were all more than those in APD goup, and the difference was significant(P<0.05). CONCLUSION The infection rates of CRRT and APD in the treatment of AKI were considerable, and CRRT group is mainly the incision infection, and APD group is mainly the abdominal infection. CRRT has a greater impact on the dosage of sensitive antibiotics, and should be attention to adjust in clinic.