Abstract: OBJECTIVE To analyze correlation between the blood uric acid (BUA) level and prognosis of infected patients in intensive care unit (ICU), so as to provide basic data for formulating effective clinical treatments. METHODS A total of 153 patients complicated with infection hospitalized in ICU from Jun. 2014 to Jun. 2016 were selected as research subjects, and were divided into death group (49 cases), improvement group (77 cases) and cured group (27 cases) according to the prognosis of the patients. The infection sites, and the acute physiology and chronic health evaluation (APACHEⅡ) score, BUA level, serum creatinine(Scr) level, blood urea oxygen (BUN) level within 24h of ICU treatment of the patients in the three groups were retrospectively analyzed. RESULTS APACHEⅡ scores of the patients in death group, improvement group and cured group were (44.03±12.06), (24.12±13.67) and (13.95±4.08), respectively, BUA levels were (0.29±0.14)mmol/L, (0.22±0.12)mmol/L and (0.17±0.10)mmol/L, respectively,Scr levels were (5.36±3.03)mmol/L, (5.11±1.75)mmol/L and (4.22±1.05)mmol/L, respectively,and BUN levels were (81.83±14.62)μmol/L, (79.57±13.24)μmol/L and (72.43±11.48)μmol/L, respectively. There were statistically significant differences of APACHEⅡ scores, BUA levels, Scr levels, and BUN levels among the three groups (P<0.05). These indexes of the patients in death group were significantly better than those in improvement group and curing group, the APACHEⅡ score and BUA level of improvement group were significantly higher than those in cured group, and the differences were statistically significant (P<0.05). Logistic multivariate regression analysis showed that the death of the infected patients in ICU was correlated with age, APACHEⅡ score or BUA level(P<0.05). CONCLUSION BUA level of the infected patients in ICU is related to the infection site and the prognosis of the patients, which can be used as a marker to predict the prognosis of the patients.