Abstract: OBJECTIVE To explore the pathogenic bacteria distribution and drug resistance of wound infection in burn patients treated with exposure therapy, so as to provide guidance for clinical treatment. METHODS A total of 102 burn patients admitted to our hospital from Oct. 2013 to Jun. 2016 were selected as research objects, and were all treated by exposure therapy. The pathogenic bacteria of secretion specimens from infected burn wounds were detected, and the drug sensitivity test and drug resistance analysis were carried out. RESULTS A total of 147 strains of bacteria were isolated from 102 cases of patients with wound infection, including 98 strains (66.67%) of gram-negative bacteria, mainly for Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae, 43 strains (29.25%) of gram-positive bacteria, mainly Staphylococcus aureus; 6 strains (4.08%) of fungi. The drug resistant rates of common gram-negative bacteria to ampicillin were more than 90%, to ampicillin/sulbactam, cefazolin, nitrofurantoin and sulfamethoxazole / trimethoprim were more than 50%, but the drug resistant rates of P.aeruginosa, E.coli and K. pneumoniae to piperacillin / tazobactam and cefepime were lower. The drug resistant rates of gram-positive bacteria to penicillin G, erythromycin, and methicillin were more than 50%, to nitrofurantoin, quinupristin/dalfopristin, tigecillin and vancomycin were 0%. CONCLUSION The pathogens of burn wound patients treated with exposure therapy were mainly gram-negative bacteria, and had strong resistance to common antibiotics. It should strengthen the detection of pathogens in clinic, and rationally use antibiotics, so as to reduce the incidence of wound infection.