Abstract: OBJECTIV To explore the influence of intraoperative comprehensive thermal insulation on postoperative infection in patients undergoing interventional surgery so as to effectively prevent the postoperative infection. METHODS A total of 1038 patients who underwent the interventional surgery in the hospital from Jan 2015 to Jun 2016 were chosen as the intervention group, which was treated with comprehensive thermal insulation program; totally 1012 patients who received the interventional surgery in the hospital from Jul 2013 to Dec 2014 were set as the control group, which was treated with conventional thermal insulation program. The body temperature 30min before the surgery and 60min after the start of surgery, operation duration, intraoperative blood loss volume, length of hospital stay, incidence of infection, and proportions of pathogens were observed and compared between the two groups of patients before and after the intervention. RESULTS Totally 62 patients had infections in the control group, with the infection rate 6.13%; totally 8 patients had infections in the intervention group, with the infection rate 0.77%, and there was significant difference between the two groups (P＜0.01). There was no significant difference in the body temperature between the two groups of patients at 30min before the surgery. After the comprehensive thermal insulation program was carried out, there was no significant difference in the body temperature of the intervention group after the start of surgery for 60 min and at the end of surgery; the body temperature of the control group was significantly lower after the start of surgery for 60min and at the end of surgery than before the surgery, as compared with the intervention group(P<0.01). There was no significant difference in the operation duration or intraoperative blood loss volume between the two groups of patients; the length of hospital stay of the control group was remarkably longer than that of the CONCLUSION Program can effectively maintain the body temperature of the patients during perioperative period, shorten the length of hospital stay, and reduce the incidence of infection after the interventional surgery.